Chloroacetaldehyde → 2-(2,3,6-Trimethylanilino)acetaldehyde

反応式

[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]([CH3:10])[C:3]=1[NH2:4].Cl[CH2:12][CH:13]=[O:14].C(=O)([O-])[O-].[Na+].[Na+]>>[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][CH:6]=[C:5]([CH3:10])[C:3]=1[NH:4][CH2:12][CH:13]=[O:14]

参加物

反応物 3

HCID 33Chloroacetaldehyde

HCID 10340Sodium Carbonate

HCID 119589472,3,6-Trimethylaniline

生成物 1

HCID 214128082-(2,3,6-Trimethylanilino)acetaldehyde

反応条件

温度: 150 °C

実験手順

2,3,6-Trimethylaniline (0.3 mole), the dimethyl acetal of 2-chloroacetaldehyde (0.3 mole) and sodium carbonate (20 grams) are charged into a glass reaction vessel equipped with a mechanical stirrer, thermometer and reflux condenser. The reaction mixture is heated at about 150°C for a period of about 8 hours. After this time the mixture is filtered and the filtrate is distilled to yield the desired product the dimethyl acetal of 2-(2,3,6-trimethylanilino)acetaldehyde.