Fumaric Acid → Votracon
反応式
[C:1]([OH:9])(=[O:8])[CH:2]([CH2:4][C:5]([OH:7])=[O:6])O.[NH2:10][C:11]1[CH:31]=[CH:30][C:14]([C:15]([N:17]([CH:19]2[CH2:23][CH2:22][N:21]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH2:20]2)[CH3:18])=[O:16])=[CH:13][CH:12]=1.C(O)(=O)/C=C/C(O)=O>C(Cl)(Cl)Cl>[C:1]([OH:9])(=[O:8])/[CH:2]=[CH:4]/[C:5]([OH:7])=[O:6].[NH2:10][C:11]1[CH:12]=[CH:13][C:14]([C:15]([N:17]([CH:19]2[CH2:23][CH2:22][N:21]([CH:24]3[CH2:29][CH2:28][CH2:27][CH2:26][CH2:25]3)[CH2:20]2)[CH3:18])=[O:16])=[CH:30][CH:31]=1参加物
4
実験手順
An aqueous solution containing 3.9 g. (0.0094 mole) of (-) 4-amino-N-(1-cyclohexyl-3-pyrrolidinyl)-N-methylbenzamide malate (Example 68) was extracted with chloroform, the chloroform solution was dried over sodium sulfate and concentrated. The residue was dissolved in ethanol, 1.2 g. (0.01 mole) of fumaric acid added and the solution refrigerated. The fumarate salt which separated weighed 3.3 g. and melted at 205°-207°C. [α]D30 = - 13.89.
後処理
- addition