Acetic Anhydride → 1-Acetamino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline

HRID 1659348ノート

反応式

HRID 1659348 の反応式
[NH2:1][C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]([C:15](=[O:17])[CH3:16])[CH:6]2[CH3:18].[C:19](OC(=O)C)(=[O:21])[CH3:20]>N1C=CC=CC=1>[NH:1]([C:2]1[CH:3]=[N:4][N:5]2[C:14]=1[C:13]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[N:7]([C:15](=[O:17])[CH3:16])[CH:6]2[CH3:18])[C:19]([CH3:20])=[O:21]

参加物

4

反応物 2

HCID 7918Acetic AnhydrideHCID 131756851-Amino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline

生成物 1

HCID 131756841-Acetamino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline収率 90%

試薬・触媒・溶媒 1

HCID 1049Pyridine溶媒

実験手順

20.5 g (0.08 mole) of 1-amino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline are dissolved in 400 ml of pyridine. 100 ml of acetic anhydride are added and the solution is left to stand at room temperature for 10 hours. A portion of the product separates as a crystalline substance, the remaining portion is separated by evaporating the mother liquor. 21.1 g (90%) of 1-acetamino-5-methyl-6-acetyl-5,6-dihydropyrazolo[1,5-c]quinazoline are obtained. M.p.: 218°-220° C.

後処理

  1. waitthe solution is left
  2. customthe remaining portion is separated
  3. customby evaporating the mother liquor

出典と根拠

ORDレコード
ord-5402d896969143129192155286193ec5
出典データセット
uspto-grants-1981_12
特許番号
US04303660

反応ノート

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