Hydrochloric Acid → 2-(3,5-Dioxo-1,2,4-triazolidin-4-yl)acetic acid
反応式
[O:1]=[C:2]1[N:6]([CH2:7][C:8]([O:10]C)=[O:9])[C:5](=[O:12])[NH:4][NH:3]1.[OH-].[Na+].Cl>>[O:1]=[C:2]1[N:6]([CH2:7][C:8]([OH:10])=[O:9])[C:5](=[O:12])[NH:4][NH:3]1参加物
4
実験手順
0.5 g (2.9 mmol) of methyl 3,5-dioxo-1,2,4-triazolidine-4-acetate was stirred at room temperature for 2 hours with 8.7 ml (8.7 mmol) of 1-M sodium hydroxide solution. The resulting solution was acidified with concentrated hydrochloric acid and evaporated to dryness. The solid residue was extracted with hot acetonitrile. The acetonitrile extracts were evaporated and the residual colourless solid was recrystallized from acetonitrile, there being obtained 0.15 g (33%) of 3,5-dioxo-1,2,4-triazolidine-4-acetic acid of melting point 220°-223° C. (from acetonitrile).
後処理
- customevaporated to dryness
- extractionThe solid residue was extracted with hot acetonitrile
- customThe acetonitrile extracts were evaporated
- customthe residual colourless solid was recrystallized from acetonitrile, there
出典と根拠
- ORDレコード
- ord-75b26e5952c944288a2a8754a147d2d3
- 出典データセット
- uspto-grants-1981_12
- 特許番号
- US04307094
反応ノート
読み込み中…