Diethyl Ether → 4-Methylbenzaldehyde
反応式
[CH:1]1([CH2:7]C2CCCCN2CC(C2C=CC=C(Br)C=2)C)[CH2:6][CH2:5]C[CH2:3][CH2:2]1.C([Li])CCC.C([O:31][CH2:32][CH3:33])C>>[CH3:7][C:1]1[CH:6]=[CH:5][C:33]([CH:32]=[O:31])=[CH:3][CH:2]=1参加物
4
実験手順
Following a procedure similar to that described in Example 3, 18.9 g. (0.05 mole) of 2-cyclohexylmethyl-1-[2-(3-bromophenyl)propyl]piperidine was reacted with 0.1 mole of n-butyl lithium in diethyl ether and the resulting lithio derivative reacted directly with 12.3 g. (0.103 mole) of 4-methylbenzaldehyde to give 16.9 g. of 2-cyclohexylmethyl-1-{2-[3-(α-hydroxy-4-methylbenzyl)phenyl]propyl}piperidine as a yellow oil.
出典と根拠
- ORDレコード
- ord-f006f223293045409fda650532781a95
- 出典データセット
- uspto-grants-1981_12
- 特許番号
- US04308382
反応ノート
読み込み中…