Hydrochloric Acid → 4-(Benzyloxy)-3-nitrobenzoic acid

HRID 1660804

反応式

HRID 1660804 の反応式
C[O:2][C:3](=[O:21])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)=[C:6]([N+:18]([O-:20])=[O:19])[CH:5]=1.CO.[OH-].[K+].Cl>O1CCCC1>[CH2:11]([O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:21])=[O:2])=[CH:5][C:6]=1[N+:18]([O-:20])=[O:19])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

参加物

6

反応物 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 289857Methyl 4-benzyloxy-3-nitrobenzoate

生成物 1

HCID 161247254-(Benzyloxy)-3-nitrobenzoic acid収率 95%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

A solution the crude 4-benzyloxy-3-nitro-benzoic acid methyl ester from the previous step in tetrahydrofurane (150 mL) and MeOH (600 mL) was treated with KOH 3N (152 mL) and stirred at room temperature for 18 hours. The mixture was acidified with HCl 3N. The precipitate thus formed was filtered, washing with MeOH/water 1:1 and dried under vacuum. 4-Benzyloxy-3-nitro-benzoic acid (42 g, 95% over two steps) was obtained as a white solid, which was used crude in the following reaction.

後処理

  1. customThe precipitate thus formed
  2. filtrationwas filtered
  3. washwashing with MeOH/water 1:1
  4. customdried under vacuum

出典と根拠

ORDレコード
ord-6161a1f249a54a6e83476b70aa6fb3b5
出典データセット
uspto-grants-2011_10
特許番号
US08030308B2

関連ノート

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