Acetonitrile → 2-(4-methoxy-pyridin-3-yl)-1H-indole-3,5-dicarbonitrile

反応式

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]1[NH:10][C:11]2[C:16]([CH:17]=1)=[CH:15][C:14]([C:18]#[N:19])=[CH:13][CH:12]=2.[C:20](#[N:22])C>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[C:9]1[NH:10][C:11]2[C:16]([C:17]=1[C:20]#[N:22])=[CH:15][C:14]([C:18]#[N:19])=[CH:13][CH:12]=2

参加物

反応物 2

HCID 6342Acetonitrile

HCID 582156342-(4-methoxy-pyridin-3-yl)-1H-indole-5-carbonitrile

生成物 1

HCID 582157722-(4-methoxy-pyridin-3-yl)-1H-indole-3,5-dicarbonitrile

実験手順

2-(4-Methoxy-pyridin-3-yl)-1H-indole-5-carbonitrile (Example 128) is processed according to the method described in Example 140, using acetonitrile instead of dichloromethane, to give 2-(4-methoxy-pyridin-3-yl)-1H-indole-3,5-dicarbonitrile. MS (ESI) m/z 275.08 (M+H)+.

出典と根拠

ORDレコード: ord-394337122d284975ae302a38eab3639f
出典データセット: uspto-grants-2011_10
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US08030334B2

反応ノート

読み込み中…