Thionyl Chloride → 2-Methoxypyridine-4-carbonyl chloride
反応式
S(Cl)([Cl:3])=O.[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=1)[C:10](O)=[O:11]>C1(C)C=CC=CC=1>[CH3:5][O:6][C:7]1[CH:8]=[C:9]([CH:13]=[CH:14][N:15]=1)[C:10]([Cl:3])=[O:11]参加物
4
反応条件
- 温度
- 80 °C
実験手順
Thionyl chloride (30.0 mL, 0.39 mol) was added to a suspension of 2-methoxy-isonicotinic acid (15.0 g, 97.9 mmol) in anhydrous toluene (150 mL). The mixture was heated at 80° C. under nitrogen for 3 hours, cooled to room temperature and filtered. The filtrate was concentrated in vacuo to afford the title compound 7.7 g (46% yield).
後処理
- temperaturecooled to room temperature
- filtrationfiltered
- concentrationThe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-fa87cee453c74028962bd64ba9e7a046
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030500B2
反応ノート
読み込み中…