(4-Bromopyridin-2-yl)methanol → 4-Bromopyridine-2-carbaldehyde

HRID 1662192ノート

反応式

HRID 1662192 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH2:8][OH:9])[CH:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[Br:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([CH:8]=[O:9])[CH:3]=1

参加物

4

反応物 1

HCID 14761462(4-Bromopyridin-2-yl)methanol

生成物 1

HCID 147614724-Bromopyridine-2-carbaldehyde

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

Manganese(IV) oxide (22.19 g, 255.29 mmol) was added to a solution of (4-bromopyridin-2-yl)methanol (4.00 g, 21.27 mmol) in chloroform (80 mL) and the reaction mixture was stirred under reflux for 45 min. After the mixture had cooled to room temperature the solids were removed by filtration through a pad of Celite®. The solvent was removed in vacuo and the residue (3.96 g, quant.) was used without further purification in the next step.

後処理

  1. temperatureunder reflux for 45 min
  2. customwere removed by filtration through a pad of Celite®
  3. customThe solvent was removed in vacuo
  4. customthe residue (3.96 g, quant.) was used without further purification in the next step

出典と根拠

ORDレコード
ord-960d209e97eb4111b6bd7889b0d46f0a
出典データセット
uspto-grants-2011_10
特許番号
US08030500B2

反応ノート

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