Thionyl Chloride → 1-Bromo-4-(chloromethyl)-2-methylbenzene
反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][C:3]=1[CH3:10].S(Cl)([Cl:13])=O>C(Cl)Cl>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][Cl:13])=[CH:4][C:3]=1[CH3:10]参加物
4
実験手順
To a stirred solution of 1.1 (2.0 g, 9.947 mmol) in DCM (50 mL) at 23° C. was added thionyl chloride (1.451 mL, 19.89 mmol) and allowed to stir overnight. The reaction was concentrated and then purified by combiflash (0 to 10% EtOAc/hexanes) to provide 1.2 (1.9940 g, 91.32% yield).
後処理
- concentrationThe reaction was concentrated
- custompurified by combiflash (0 to 10% EtOAc/hexanes)
出典と根拠
- ORDレコード
- ord-f47f4f7a08054c05abdd60d670efe7bf
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030354B2
反応ノート
読み込み中…