Thionyl Chloride → 2-Bromo-5-(chloromethyl)phenyl butyl ether

HRID 1662337ノート

反応式

HRID 1662337 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8]O)=[CH:4][C:3]=1[O:10][CH2:11][CH2:12][CH2:13][CH3:14].S(Cl)([Cl:17])=O>C(Cl)Cl>[CH2:11]([O:10][C:3]1[CH:4]=[C:5]([CH2:8][Cl:17])[CH:6]=[CH:7][C:2]=1[Br:1])[CH2:12][CH2:13][CH3:14]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 57705850(4-Bromo-3-(butyloxy)phenyl)methanol

生成物 1

HCID 577063052-Bromo-5-(chloromethyl)phenyl butyl ether収率 92%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a stirred solution of 20.2 (659.3 mg, 2544 μmol) in DCM (15 mL) at 23° C., was added thionyl chloride (371 μL, 5088 μmol). The resulting mixture was stirred overnight. The reaction was concentrated and then purified by combiflash (0 to 10% EtOAc/Hexanes) to provide 20.3 (650 mg, 92.0% yield).

後処理

  1. concentrationThe reaction was concentrated
  2. custompurified by combiflash (0 to 10% EtOAc/Hexanes)

出典と根拠

ORDレコード
ord-196a25fc8e724315a14d556eab312c94
出典データセット
uspto-grants-2011_10
特許番号
US08030354B2

反応ノート

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