Methyl 3-(3-(benzyloxy)phenyl)-4-methoxybut-2-enoate → Methyl 3-(3-hydroxyphenyl)-4-methoxybutanoate
反応式
C([O:8][C:9]1[CH:10]=[C:11]([C:15]([CH2:21][O:22][CH3:23])=[CH:16][C:17]([O:19][CH3:20])=[O:18])[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1>CCOC(C)=O.[Pd]>[OH:8][C:9]1[CH:10]=[C:11]([CH:15]([CH2:21][O:22][CH3:23])[CH2:16][C:17]([O:19][CH3:20])=[O:18])[CH:12]=[CH:13][CH:14]=1参加物
4
実験手順
To a solution of 102.B (mixture of geometric isomers) (0.11 g, 0.35 mmol) in EtOAc (2 mL) was added Pd/C (10 wt. %) (0.019 g, 0.018 mmol) under N2. The mixture was purged with H2, stirred overnight under a H2 balloon, filtered through silica gel (EtOAc), and concentrated. The crude product was purified by silica gel flash chromatography (10-40% EtOAc/hexane) to afford 102.C (0.060 g, 76%) as a pale yellow oil.
後処理
- customThe mixture was purged with H2
- filtrationfiltered through silica gel (EtOAc)
- concentrationconcentrated
- customThe crude product was purified by silica gel flash chromatography (10-40% EtOAc/hexane)
出典と根拠
- ORDレコード
- ord-2e950100b36949dbae0eae8dc49346fc
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030354B2
反応ノート
読み込み中…