Water → HCID 18736636、化合物
反応式
CI.[F:3][CH:4]([F:13])[O:5][C:6]1[CH:7]=[C:8]([OH:12])[CH:9]=[CH:10][CH:11]=1.[C:14]([O-])([O-])=O.[K+].[K+].O>CN(C=O)C>[F:3][CH:4]([F:13])[O:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][CH3:14])[CH:7]=1参加物
6
実験手順
2.67 g of methyl iodide was stirred on ice in a suspension of 2.00 g of 3-difluoromethoxy phenol and 2.60 g of K2CO3 in DMF (10 ml) at room temperature for two hours. Water was added to the solution and the resulting mixture was extracted with Et2O; the organic layer was washed with saturated brine and then dried over MgSO4; the drying agent was separated by filtration, and the solvent was evaporated under reduced pressure obtained 46.0 g of the title compound (crude form).
後処理
- extractionthe resulting mixture was extracted with Et2O
- washthe organic layer was washed with saturated brine
- dry with materialdried over MgSO4
- customthe drying agent was separated by filtration
- customthe solvent was evaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-899b08c2cdff46f19bf6c95af998010d
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08030499B2
反応ノート
読み込み中…