Ethyl Acetate → HCID 22387088、化合物
反応式
[CH2:1]([C:4]1[CH:5](O)[C:6](=[O:9])[O:7][CH:8]=1)[CH2:2][CH3:3].C(OCC)(=[O:13])C>[Pd]>[OH:13][C:8]1[O:7][C:6](=[O:9])[CH2:5][C:4]=1[CH2:1][CH2:2][CH3:3]参加物
4
反応条件
- 温度
- 25 °C
実験手順
5-hydroxy-4-propyl-5H-furan-2-one 373 (15 g, 0.1 mol), ethyl acetate (260 ml) and Pd/C5% are placed in a Parr apparatus. The mixture is degassed, and hydrogen is introduced at a pressure of 35 psi. This mixture is then stirred vigorously at 25° C. for 2 h. After filtration on celite, the solvent is removed under reduced pressure at 50° C. to give the 5-hydroxy-4-propyl-furan-2-one as a crude product (100% yield). LC/MS: 145 (MH+).
後処理
- customThe mixture is degassed
- additionhydrogen is introduced at a pressure of 35 psi
- filtrationAfter filtration on celite
- customthe solvent is removed under reduced pressure at 50° C.
出典と根拠
- ORDレコード
- ord-8c66e806a1f64200a846b4ea3eaa16c6
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08034958B2
反応ノート
読み込み中…