Sodium Phosphate, Dibasic → Ethyl 6-Iodoimidazo[1,2-b]pyridazine-2-carboxylate
反応式
[NH2:1][C:2]1[N:3]=[N:4][C:5]([I:8])=[CH:6][CH:7]=1.Br[CH2:10][C:11](=O)[C:12]([O:14][CH2:15][CH3:16])=[O:13].P([O-])([O-])(O)=O.[Na+].[Na+]>CN(C)C(=O)C>[I:8][C:5]1[CH:6]=[CH:7][C:2]2[N:3]([CH:10]=[C:11]([C:12]([O:14][CH2:15][CH3:16])=[O:13])[N:1]=2)[N:4]=1参加物
5
実験手順
Using 3-amino-6-iodopyridazine (2.0 g, 9.05 mmol), N,N-dimethylacetamide (20 mL), ethyl 3-bromo-2-oxopropanate (1.82 mL, 14.5 mmol) and disodium hydrogenphosphate (3.21 g, 22.6 mmol), and in the same manner as in Reference Example 3, the title compound (1.2 g, 44%) was obtained as a green powder.
出典と根拠
- ORDレコード
- ord-d574023b2be34a56b8b33cb5c80cc813
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08034812B2
反応ノート
読み込み中…