Sodium Hydroxide → 1-methyl-1H-1,2,3-triazole-5-carboxylic acid
反応式
[CH3:1][N:2]1[C:6]([C:7]([O:9]CC)=[O:8])=[CH:5][N:4]=[N:3]1.[OH-].[Na+]>CO>[CH3:1][N:2]1[C:6]([C:7]([OH:9])=[O:8])=[CH:5][N:4]=[N:3]1参加物
4
実験手順
To a solution of ethyl 1-methyl-1H-1,2,3-triazole-5-carboxylate (1.15 g, 7.41 mmol) in methanol (17 mL) was added 1N sodium hydroxide (11.5 mL), and the mixture was stirred at room temperature for 1 hr. Methanol was evaporated under reduced pressure, 1N hydrochloric acid (12 mL) was added to the mixture, the precipitated crystals were collected by filtration and washed with water. The crystals were vacuum dried at 90° C. to give the title compound (148 mg, 16%) as a white powder.
後処理
- customMethanol was evaporated under reduced pressure, 1N hydrochloric acid (12 mL)
- additionwas added to the mixture
- filtrationthe precipitated crystals were collected by filtration
- washwashed with water
- customdried at 90° C.
出典と根拠
- ORDレコード
- ord-8b0057b026044ab0bfd074dab529d741
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08034812B2
反応ノート
読み込み中…