Sodium Hydroxide → 1,4-Dimethyl-1H-pyrazole-3-carboxylic acid

HRID 1663637

反応式

HRID 1663637 の反応式
[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([O:10]CC)=[O:9])=[N:3]1.[OH-].[Na+]>C(O)C>[CH3:1][N:2]1[CH:6]=[C:5]([CH3:7])[C:4]([C:8]([OH:10])=[O:9])=[N:3]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 10749618ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate

生成物 1

HCID 53256851,4-Dimethyl-1H-pyrazole-3-carboxylic acid収率 41.4%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Using ethyl 1,4-dimethyl-1H-pyrazole-3-carboxylate (440 mg, 2.62 mmol), 1N aqueous sodium hydroxide solution (3 mL, 3 mmol) and ethanol (3 mL), and by a reaction in the same manner as in Reference Example 20, the title compound (152 mg, 41%) was obtained as pale-yellow crystals.

後処理

  1. customby a reaction in the same manner as in Reference Example 20

出典と根拠

ORDレコード
ord-664c37f6d3494bb4a3ba7dd38434d8f8
出典データセット
uspto-grants-2011_10
特許番号
US08034812B2

関連ノート

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