Hydrochloric Acid → 870562-26-8
反応式
[C:1]([C:3]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[C:6]([F:13])=[CH:5][CH:4]=1)#[N:2].[ClH:14]>C(O)C.[Pd]>[ClH:14].[F:13][C:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:3]([CH2:1][NH2:2])=[CH:4][CH:5]=1参加物
5
実験手順
A solution of 1-cyano-4-fluoronapthalene (1.05 g, 6.12 mmol) and 1.5 mL of HCl (aq.) in absolute ethanol (50 mL) was stirred under a hydrogen atmosphere (balloon) with 10% palladium on carbon (0.20 g) for 16 hours. The catalyst was removed by filtration through Celite®, and the filtrate concentrated under vacuum. The resulting solid was triturated with ether and collected by filtration to give the title compound (0.575 g, 44% yield) as an off white solid.
後処理
- customThe catalyst was removed by filtration through Celite®
- concentrationthe filtrate concentrated under vacuum
- customThe resulting solid was triturated with ether
- filtrationcollected by filtration
出典と根拠
- ORDレコード
- ord-58a07d8afd314eb8ad52cd16eec93d0c
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039458B2
反応ノート
読み込み中…