Potassium Carbonate → HCID 67439609、化合物

HRID 1664207

反応式

HRID 1664207 の反応式
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([C:13](Cl)=[O:14])[CH:5]=1.C([O-])([O-])=O.[K+].[K+].[CH3:23][O:24][CH:25]([O:28][CH3:29])[CH2:26][NH2:27]>C(Cl)Cl.C(OCC)(=O)C>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[CH:7]=[C:6]([C:13]([NH:27][CH2:26][CH:25]([O:28][CH3:29])[O:24][CH3:23])=[O:14])[CH:5]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 74774Methyl 3-(chlorocarbonyl)-5-nitrobenzoateHCID 89728Aminoacetaldehyde dimethyl acetal

生成物 1

HCID 67439609HCID 67439609、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒2 回HCID 8857Ethyl Acetate溶媒

実験手順

Under ice cooling a solution of 22.1 g (90.7 mmol) of 3-chlorocarbonyl-5-nitro-benzoic acid methyl ester (U.S. Pat. No. 4,120,891) in 200 ml of DCM is added dropwise to a stirred suspension of 11.2 g (181 mmol) of K2CO3 and 11.7 ml (109 mmol) of aminoacetaldehyde dimethylacetal in 200 ml of DCM. The mixture is stirred at ambient temperature for 2 days, diluted with ethyl acetate and extensively washed with water. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.

後処理

  1. washextensively washed with water
  2. dry with materialThe organic phase is dried over sodium sulfate
  3. customevaporated
  4. customto yield the product in the form of a yellow oil

出典と根拠

ORDレコード
ord-5168e8333bb54d3397d3ae3a4e195b8b
出典データセット
uspto-grants-2011_10
特許番号
US08039455B2

関連ノート

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