アミノアセトアルデヒドジメチルアセタール

Aminoacetaldehyde dimethyl acetal

HCID 89728CAS 22483-09-6

基本情報

標準SMILES
COC(CN)OC
InChIKey
QKWWDTYDYOFRJL-UHFFFAOYSA-N
分子式
C4H11NO2
平均分子量
105.14 g/mol
単同位体質量
105.07897859

名称と識別子

優先名称
Aminoacetaldehyde dimethyl acetal
IUPAC
2,2-dimethoxyethanamine
現地名
アミノアセトアルデヒドジメチルアセタール
英語名
Aminoacetaldehyde dimethyl acetal
分子式
C4H11NO2
分子量
105.14

名称と別名

22483-09-6Aminoacetaldehyde dimethyl acetal2,2-Dimethoxyethylamine2,2-DimethoxyethanamineEthanamine, 2,2-dimethoxy-Acetaldehyde, amino-, dimethyl acetalXF4JYB7VV5EINECS 245-026-5NSC 73701NSC-73701DTXSID7066803ETHYLAMINE, 2,2-DIMETHOXY-
名称をさらに表示
アミノアセトアルデヒドジメチルアセタール2-アミノアセトアルデヒドジメチルアセタール(2,2-ジメトキシエチル)アミン2,2-ジメトキシエタンアミン2,2-ジメトキシエチルアミンアミノアセトアルデヒド ジメチル アセタル2,2ジメトキシエチルアミン2,2-ジメトキシエチルアミン アミノアセトアルデヒドジメチルアセタールアミノアセトアルデヒドジメチルアセタール, 99%2,2-ジメトキシエタン-1-アミン2,2-dimethoxy-ethanaminAMINOACETOLDEHYDE DIMETHYL ACETOL2,2-Dimethyethanamine2-AMINOACETALDEHYDE DIMETHYLACETALAminoacetaldehyde dimethyl acetal ,98%AMINOACETALDEHYDE DIMETHYL ACETAL (OR) 2,2- DIMETHOXYETHYLAMINE (ADMA)anjiahuanchun
RefChem:557526DTXCID1036709Acetaldehyde, amino-, dimethyl acetal (8CI)2,2-DIMETHOXYETHAN-1-AMINEGlycinal Dimethyl AcetalMFCD000081352,2-dimethoxy-ethylamine2-AMINOACETALDEHYDE DIMETHYL ACETAL

データベース識別子

CAS
22483-09-6
PubChem CID
89728
DTXSID
DTXSID7066803
UNII
XF4JYB7VV5
EC Number
245-026-5
Nikkaji
J26.136J

物性

構造計算による物性

XLogP
-0.8
極性表面積
44.5 Ų
水素結合供与体数
1
水素結合受容体数
3
回転可能結合数
3
重原子数
7

実験および物理化学的性質

SpringerMaterials PropertiesOptical coefficient
Density0.957 @25 °C
Boiling Point128 °C @760 [mm Hg]
Melting Point-45 °C
Vapor Pressure7.5 [mm Hg] @20 °C

物理化学的性質

融点
-78 °C · -78°C
沸点
135 · 135-139 °C/95 mmHg (lit.)
比重(密度)
0.965 g/mL · 0.965 g/mL at 25 °C (lit.)
屈折率
20 · n20/D 1.417(lit.)
闪点
128 °F · 128 °F
貯蔵温度
2 · Keep in dark place,Inert atmosphere,2-8°C

化学的性質

化学的特性clear colorless to pale yellow liquid

安全と法規制

GHS分類

GHS Classification · 5 件

This chemical does not meet GHS hazard criteria for 1.4% (1 of 69) of reports.

Danger

H226 (98.6%): Flammable liquid and vapor [Warning Flammable liquids]

P210, P233, P240, P241, P242, P243, P260, P264, P280, P301+P330+P331, P302+P361+P354, P303+P361+P353, P304+P340, P305+P354+P338, P316, P321, P363, P370+P378, P403+P235, P405, and P501 (click each P-code to see the statement)

Aggregated GHS information provided per 69 reports by companies from 7 notifications to the ECHA C&L Inventory. Each notification may be associated with multiple companies.

危険有害性情報

Regulatory Information · 3 件

Chemical: Ethanamine, 2,2-dimethoxy-

Status: Active Update: 04-03-2021 https://echa.europa.eu/registration-dossier/-/registered-dossier/21032

Aminoacetaldehyde dimethyl acetal: Does not have an individual approval but may be used under an appropriate group standard

Hazard Classes and CategoriesFlam. Liq. 3 (98.6%)

安全と保護具

Protective Action Criteria (PAC) · 3 件

12 [mg/m3]

130 [mg/m3]

790 [mg/m3]

安全データ

wgk
2
tsca
TSCA listed
ridadr
UN 1993 3/PG 3
hs_code
29225000
risk_code
10-34-36/37/38
消防法
危-4-2-III

化学と産業

用途と製造

General Manufacturing InformationEthanamine, 2,2-dimethoxy-: ACTIVE
応用分野 · 4 件

用途試験研究用、医薬中間体。

説明Aminoacetaldehyde dimethyl acetal, also known as 2,2-dimethoxy-ethylamine, is a critical intermediate in the synthesis of ivabradine hydrochloride, proline analogs, praziquantel, and other raw materials. The existing process for producing aminoacetal dimethyl acetate uses vinyl acetate as the starting material, and the target product is synthesized through bromination, Gabriel synthesis, and hydrazinolysis.

使用Amino acetaldehyde dimethyl was used in preparation of chitosan- dendrimer hybrids having various functional groups such as carboxyl, ester and poly(ethylene glycol). It was used in an synthesis of a bicyclic proline analog from L-ascorbic acid and in 3-component reaction catalyzed by MgClO4 leading to α-aminophosphonates.

一般的な説明Aminoacetaldehyde dimethyl acetal reacts with sulfone, followed by hydrolysis and reductive amination by adding desired piperazine derivative to yield piperazine derivatives of 2-furanyl[1,2,4]triazolo[1,5-a][1,3,5]triazine.

調製方法

純化方法Dry the acetal over KOH pellets and distil it through a 30cm vacuum jacketed Vigreux column (p 11). [Lawson J Am Chem Soc 75 3398 1953, Erickson et al. J Am Chem Soc 77 6640 1955, Beilstein 4 IV 1918.]

サプライヤー50 社

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北京华美互利生物化工010-56205725 · [email protected]
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