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Ethyl Acetate → 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl Acetate | HCID 8857 | — |
| 反応物 | N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester | HCID 67439609 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 5-Nitro-N-(2-oxo-ethyl)-isophthalamic acid methyl ester | HCID 86626579 | — |
反応手順
A mixture of 29.7 g (95.1 mmol) of N-(2,2-dimethoxy-ethyl)-5-nitro-isophthalamic acid methyl ester in 300 ml of THF and 300 ml of 2N HCl is stirred overnight. Ethyl acetate is added, and the mixture is washed twice with brine. The organic phase is dried over sodium sulfate and evaporated to yield the product in the form of a yellow oil.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08039455B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-1612f793da6a4beda7e6ce3a5b6b8e03 |
| 出典メモ | uspto-grants-2011_10 |