Trifluoroacetic acid → 9-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one

HRID 1664549ノート

反応式

HRID 1664549 の反応式
[CH2:1]([N:6]1[C:14]2[N:13]=[CH:12][NH:11][C:10]=2[C:9](=[O:15])[NH:8]/[C:7]/1=[N:16]\[NH2:17])[CH2:2][CH2:3][CH2:4][CH3:5].[F:18][C:19]([F:24])([F:23])[C:20](O)=O>>[CH2:1]([N:6]1[C:14]2[N:13]=[CH:12][NH:11][C:10]=2[C:9](=[O:15])[N:8]2[C:20]([C:19]([F:24])([F:23])[F:18])=[N:17][N:16]=[C:7]12)[CH2:2][CH2:3][CH2:4][CH3:5]

参加物

3

反応物 2

HCID 6422Trifluoroacetic acidHCID 178446164HCID 178446164、化合物

生成物 1

HCID 576003029-pentyl-3-(trifluoromethyl)-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one収率 60.2%

実験手順

The mixture of (2E)-3-pentyl-3,7-dihydro-1H-purine-2,6-dione 2-hydrazone (200 mg, 0.85 mmol) in trifluoroacetic acid (10 mL) was refluxed overnight. The reaction mixture was concentrated and purified by preparative LCMS to yield the desired product (160 mg, 60.2%). LCMS calculated for C12H14F3N6O (M+H): 315.1. found 315.0.

後処理

  1. temperaturewas refluxed overnight
  2. concentrationThe reaction mixture was concentrated
  3. custompurified by preparative LCMS

出典と根拠

ORDレコード
ord-acc5a34b2e0548a1b00fa8d657fd011e
出典データセット
uspto-grants-2011_10
特許番号
US08039478B2

反応ノート

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