Hydrochloric Acid → HCID 66725663、化合物

HRID 1664570ノート

反応式

HRID 1664570 の反応式
[O:1]=[C:2]1[N:10]2[C:11]([CH2:14][NH:15]C(=O)OCC3C=CC=CC=3)=[N:12][N:13]=[C:9]2[N:8]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:7]2[N:6]=[CH:5][NH:4][C:3]1=2.[ClH:31]>CO.[Pd]>[ClH:31].[NH2:15][CH2:14][C:11]1[N:10]2[C:2](=[O:1])[C:3]3[NH:4][CH:5]=[N:6][C:7]=3[N:8]([CH2:26][CH2:27][CH2:28][CH2:29][CH3:30])[C:9]2=[N:13][N:12]=1

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 57600256benzyl[(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate

生成物 1

HCID 66725663HCID 66725663、化合物収率 92%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To the solution of benzyl [(5-oxo-9-pentyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-3-yl)methyl]carbamate (0.30 g, 0.73 mmol) in methanol (20 mL) and 1 mL of conc. HCl was added 10% Pd/C under N2. The mixture was shaken under 30 PSI H2 for 3 hours. The reaction mixture was filtered through celite and concentrated to yield the desired product (210 mg, 92%). LCMS calculated for C12H18N7O (M+H): 276.2. found: 276.2.

後処理

  1. filtrationThe reaction mixture was filtered through celite and
  2. concentrationconcentrated

出典と根拠

ORDレコード
ord-e9f6b7cd71e54d928119dd9ff0a957bd
出典データセット
uspto-grants-2011_10
特許番号
US08039478B2

反応ノート

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