Benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate → HCID 57562526、化合物
反応式
[O:1]=[C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11](C(OCC3C=CC=CC=3)=O)[CH2:10][CH2:9]2)=[CH:6][CH:5]=[N:4][NH:3]1>C(O)C.[Pd]>[NH:11]1[CH2:10][CH2:9][CH:8]([C:7]2[C:2](=[O:1])[NH:3][N:4]=[CH:5][CH:6]=2)[CH2:13][CH2:12]1参加物
4
実験手順
A solution of benzyl 4-(3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate (0.90 mg, 2.88 mmol) and 10% Pd/C (500 mg) in ethanol (25 mL), was hydrogenated under a balloon for 4 h. The reaction was filtered through celite, washed with ethanol and concentrated to give the title compound (465 mg). MS 180.1 (M+1).
後処理
- filtrationThe reaction was filtered through celite
- washwashed with ethanol
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-ed653b2a96dd4bd9a26315893932faf8
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039460B2
反応ノート
読み込み中…