HCID 67438530、化合物 → HCID 59722662、化合物
反応式
[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH2:13][N:12](C(OCC3C=CC=CC=3)=O)[CH2:11][CH2:10]2)[C:5](=[O:8])[NH:6][N:7]=1>C(O)C.[Pd]>[CH3:1][C:2]1[CH:3]=[C:4]([CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[C:5](=[O:8])[NH:6][N:7]=1参加物
4
実験手順
Palladium (10% on carbon; 0.70 g) was added to a solution of benzyl 4-(6-methyl-3-oxo-2,3-dihydropyridazin-4-yl)piperidine-1-carboxylate (1.45 g, 4.43 mmol) in ethanol (100 mL). The reaction vessel was evacuated and back-filled with nitrogen (3×), then back-filled with hydrogen (1 atm). After 24 h, the mixture was filtered through celite and concentrated to give the title compound (0.86 g). MS 194.1 (M+1).
後処理
- customThe reaction vessel was evacuated
- additionback-filled with nitrogen (3×)
- additionback-filled with hydrogen (1 atm)
- filtrationthe mixture was filtered through celite and
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-7fbbdfa362a646ee968296990601ae96
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039460B2
反応ノート
読み込み中…