Isobutylamine → [(4-Bromothiophen-2-yl)methyl](2-methylpropyl)amine

HRID 1665028

反応式

HRID 1665028 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.[CH2:9]([NH2:13])[CH:10]([CH3:12])[CH3:11].[BH4-].[Na+]>CO>[Br:1][C:2]1[CH:3]=[C:4]([CH2:7][NH:13][CH2:9][CH:10]([CH3:12])[CH3:11])[S:5][CH:6]=1

参加物

5

反応物 3

HCID 6558IsobutylamineHCID 877924-Bromothiophene-2-carbaldehydeHCID 4311764Sodium borohydride

生成物 1

HCID 28833175[(4-Bromothiophen-2-yl)methyl](2-methylpropyl)amine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

In analogy to example 13, step 1, 4-bromothiophene-2-carboxaldehyde was reacted with isobutylamine and sodium borohydride in methanol to give (4-bromo-thiophen-2-ylmethyl)-isobutyl-amine as a colorless oil.

出典と根拠

ORDレコード
ord-3d5f507874dc48bc96d77f2f83c6edd3
出典データセット
uspto-grants-2011_10
特許番号
US08039493B2

関連ノート

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