2-Chlorobenzenesulfonyl chloride → N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide

HRID 1665029

反応式

HRID 1665029 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH2:7][NH:8][CH2:9][CH:10]([CH3:12])[CH3:11])[S:5][CH:6]=1.[Cl:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][C:15]=1[S:20](Cl)(=[O:22])=[O:21].C(N(CC)C(C)C)(C)C>ClCCl>[Br:1][C:2]1[CH:3]=[C:4]([CH2:7][N:8]([CH2:9][CH:10]([CH3:12])[CH3:11])[S:20]([C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=2[Cl:13])(=[O:22])=[O:21])[S:5][CH:6]=1

参加物

5

反応物 3

HCID 761872-Chlorobenzenesulfonyl chlorideHCID 81531DiisopropylethylamineHCID 28833175[(4-Bromothiophen-2-yl)methyl](2-methylpropyl)amine

生成物 1

HCID 67439155N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In analogy to example 13, step 2, (4-bromo-thiophen-2-ylmethyl)-isobutyl-amine was reacted with 2-chlorobenzenesulfonylchloride in presence of N,N-diisopropyl ethyl amine in dichloromethane to give N-(4-bromo-thiophen-2-ylmethyl)-2-chloro-N-isobutyl-benzenesulfonamide as a colorless oil.

出典と根拠

ORDレコード
ord-08e901e300cb46c0a20f0af16c99040d
出典データセット
uspto-grants-2011_10
特許番号
US08039493B2

関連ノート

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