4-nitro-1-phenyl-1H-pyrazole → 1-Phenyl-1H-pyrazol-4-amine
反応式
[N+:1]([C:4]1[CH:5]=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1)([O-])=O>CO.CCOC(C)=O.[Pd]>[NH2:1][C:4]1[CH:5]=[N:6][N:7]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)[CH:8]=1参加物
5
実験手順
10% Pd/C (25 mg) was added to a stirred solution of 4-nitro-1-phenyl-1H-pyrazole (240 mg, 1.2 mmol) in a mixture of MeOH (2.5 mL) and EtOAc (2.5 mL) and stirred under H2 atmosphere overnight. The reaction mixture was filtered through celite and the filtrate so obtained was concentrated under reduced pressure to afford 140 mg (69365% Yield) of 4-amino-1-phenyl-1H-pyrazole.
後処理
- filtrationThe reaction mixture was filtered through celite
- customthe filtrate so obtained
- concentrationwas concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-345f202434ea4f7fbb743edc229a4c99
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039463B2
反応ノート
読み込み中…