1'-Benzyl-5H-spiro[furo[3,4-b]pyridine-7,4'-piperidine] → 5H-Spiro[furo[3,4-b]pyridine-7,4'-piperidine]
反応式
C([N:8]1[CH2:13][CH2:12][C:11]2([C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[CH2:15][O:14]2)[CH2:10][CH2:9]1)C1C=CC=CC=1>C(O)C.[Pd]>[NH:8]1[CH2:9][CH2:10][C:11]2([C:17]3=[N:18][CH:19]=[CH:20][CH:21]=[C:16]3[CH2:15][O:14]2)[CH2:12][CH2:13]1参加物
4
実験手順
A solution of 0.39 g (1.4 mmol) 1′-benzyl-5H-spiro[furo[3,4-b]pyridine-7,4′-piperidine] in 14 ml ethanol was purged with argon prior to adding 0.15 g (10 mol %) palladium on activated charcoal. The flask was evacuated, refilled with hydrogen gas and stirred at room temperature under an atmosphere of hydrogen for 16 h. The catalyst was filtered off and washed with ethanol. The filtrate was concentrated to dryness to give the title compound (0.24 g, 91%) as an amorphous solid.
後処理
- customThe flask was evacuated
- additionrefilled with hydrogen gas
- filtrationThe catalyst was filtered off
- washwashed with ethanol
- concentrationThe filtrate was concentrated to dryness
出典と根拠
- ORDレコード
- ord-fc7047be007b4e629b58da8d7e9d45a0
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08039624B2
反応ノート
読み込み中…