3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-5-nitro-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide → 3-{5-Amino-6-[(2,2-dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide

HRID 1666079ノート

反応式

HRID 1666079 の反応式
[CH3:1][C:2]([CH3:28])([CH3:27])[CH2:3][N:4]([CH3:26])[C:5]1[N:10]=[CH:9][N:8]=[C:7]([NH:11][C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][C:21]=2[CH3:22])[C:15]([NH:17][CH3:18])=[O:16])[C:6]=1[N+:23]([O-])=O.[H][H]>[Pd]>[NH2:23][C:6]1[C:7]([NH:11][C:12]2[CH:13]=[C:14]([CH:19]=[CH:20][C:21]=2[CH3:22])[C:15]([NH:17][CH3:18])=[O:16])=[N:8][CH:9]=[N:10][C:5]=1[N:4]([CH2:3][C:2]([CH3:28])([CH3:27])[CH3:1])[CH3:26]

参加物

4

反応物 2

HCID 102001653-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-5-nitro-pyrimidin-4-ylamino}-4,N-dimethyl-benzamideHCID 178418361HCID 178418361、化合物

生成物 1

HCID 99467743-{5-Amino-6-[(2,2-dimethyl-propyl)-methyl-amino]-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide収率 84.2%

試薬・触媒・溶媒 1

HCID 23938Palladium触媒

実験手順

3-{6-[(2,2-Dimethyl-propyl)-methyl-amino]-5-nitro-pyrimidin-4-ylamino}-4,N-dimethyl-benzamide (0.31 g, 0.8 mmol)) was hydrogenated under 40 psi of hydrogen pressure in the presence of 10% Pd/C for 4 hours in Parr instrument. The catalyst was filtered off through celite and the filtrate was concentrated to afford the product (0.24 g, yield 84%). MS (m/z): 357 (M+H).

後処理

  1. filtrationThe catalyst was filtered off through celite
  2. concentrationthe filtrate was concentrated

出典と根拠

ORDレコード
ord-c572ad1026774538952ea24db22d4c59
出典データセット
uspto-grants-2011_10
特許番号
US08044040B2

反応ノート

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