Ethanolamine → 8-{2-[2-(4-bromophenyl)-1,1-dimethylethylamino]-1-hydroxyethyl}-6-hydroxy-4H-benzo[1,4]oxazin-3-one
反応式
C(CN)O.C([O:12][C:13]1[CH:14]=[C:15]([C:24](=[O:28])[CH:25](O)O)[C:16]2[O:21][CH2:20][C:19](=[O:22])[NH:18][C:17]=2[CH:23]=1)C1C=CC=CC=1.[Br:29][C:30]1[CH:35]=[CH:34][C:33]([CH2:36][C:37]([NH2:40])([CH3:39])[CH3:38])=[CH:32][CH:31]=1>>[Br:29][C:30]1[CH:31]=[CH:32][C:33]([CH2:36][C:37]([NH:40][CH2:25][CH:24]([C:15]2[C:16]3[O:21][CH2:20][C:19](=[O:22])[NH:18][C:17]=3[CH:23]=[C:13]([OH:12])[CH:14]=2)[OH:28])([CH3:38])[CH3:39])=[CH:34][CH:35]=1参加物
4
実験手順
The preparation of the ethanolamine and debenzylation were carried out as described in Example 19 from 300 mg (0.91 mmol) of 6-benzyloxy-8-(2,2-dihydroxy-acetyl)-4H-benzo[1,4]oxazin-3-one and 250 mg (1.09 mmol) of 2-(4-bromophenyl)-1,1-dimethylethylamine. Beige solid. Yield: 54 mg (14%); mass spectrometry: [M+H]+=435, 437.