[4-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)phenyl]methanol → 4-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)benzaldehyde

HRID 1666204ノート

反応式

HRID 1666204 の反応式
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:33][CH3:34])[N:6]2[CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:30]=[CH:29][C:28]([CH2:31][OH:32])=[CH:27][CH:26]=2)[CH2:20][CH2:19]1>[O-2].[O-2].[Mn+4].C(Cl)(Cl)Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:33][CH3:34])[N:6]2[CH2:16][CH2:17][CH:18]1[CH2:23][CH2:22][N:21]([CH2:24][C:25]2[CH:26]=[CH:27][C:28]([CH:31]=[O:32])=[CH:29][CH:30]=2)[CH2:20][CH2:19]1

参加物

4

反応物 1

HCID 59288029[4-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)phenyl]methanol

生成物 1

HCID 592880284-(4-{2-[6-Amino-8-methoxy-2-(2-methoxyethoxy)purin-9-yl]ethyl}-piperidin-1-ylmethyl)benzaldehyde収率 92%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

The compound (0.52 g, 1.10 mmol) obtained in Step (i) and manganese dioxide (0.95 g, 11.0 mmol) were added to chloroform (20 ml), and the mixture was stirred at room temperature for 15 hours. The mixture was filtered, and the filtrate was concentrated. The residue was purified by silica gel column (chloroform/methanol=100/1 to 50/1) to give the subtitle compound (0.47 g, 1.00 mmol) as a white solid. Yield: 92%.

後処理

  1. filtrationThe mixture was filtered
  2. concentrationthe filtrate was concentrated
  3. customThe residue was purified by silica gel column (chloroform/methanol=100/1 to 50/1)

出典と根拠

ORDレコード
ord-a92d55ffa30b49ef815a629de1aacc34
出典データセット
uspto-grants-2011_10
特許番号
US08044056B2

反応ノート

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