ホームMCPワークベンチSkills
ホームワークベンチ通知マイページ
llms.txt · MCPガイドプライバシーポリシー · 利用規約 · サポートv1.8.0
  1. ホーム
  2. /反応

1,1'-Carbonyldiimidazole → 2-(3,4,5-Trimethoxyphenyl)-2-acetoxy-n-methyl-n-3,4-ethylenedioxybenzylacetamide

HRID 1666298
ノート
印刷プレビュー

反応式

HRID 1666298 の反応式
[C:1]([O:4][CH:5]([C:9]1[CH:14]=[C:13]([O:15][CH3:16])[C:12]([O:17][CH3:18])=[C:11]([O:19][CH3:20])[CH:10]=1)[C:6]([OH:8])=O)(=[O:3])[CH3:2].[C:21](N1C=CN=C1)([N:23]1C=CN=[CH:24]1)=[O:22].CNC[C:36]1[CH:41]=[CH:40][C:39]2O[CH2:43][CH2:44][O:45][C:38]=2[CH:37]=1>ClCCl>[CH3:20][O:19][C:11]1[CH:10]=[C:9]([C:5]2([O:4][C:1](=[O:3])[CH3:2])[C:6]3[O:8][CH2:43][CH2:44][O:45][C:38]=3[CH:37]=[CH:36][CH:41]2[CH2:40][CH2:39][C:21]([NH:23][CH3:24])=[O:22])[CH:14]=[C:13]([O:15][CH3:16])[C:12]=1[O:17][CH3:18]
参加物実験手順後処理出典と根拠反応ノート

参加物

5

反応物 3

HCID 682631,1'-CarbonyldiimidazoleHCID 38711271-(2,3-Dihydro-1,4-benzodioxin-6-yl)-N-methylmethanamineHCID 67081678alpha-Acetoxy-3,4,5-trimethoxyphenyl-acetic acid

生成物 1

HCID 1317292402-(3,4,5-Trimethoxyphenyl)-2-acetoxy-n-methyl-n-3,4-ethylenedioxybenzylacetamide収率 92.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane
溶媒
2 回

実験手順

A solution of α-acetoxy-3,4,5-trimethoxyphenyl-acetic acid (5.0 g) in dichloromethane (40 ml) was reacted with 1,1′-carbonyldiimidazole (2.92 g) at room temperature for 30 minutes. The solution was refluxed for 30 minutes, after which N-methyl-3,4-ethylenedioxybenzylamine (3.26 g) dissolved in dichloromethane (10 ml) was added. The mixture was stirred at room temperature for 2 hours, after which it was washed with aqueous hydrochloric acid (20 ml, 1M) followed by aqueous sodium hydrogen carbonate (20 ml, 0.5 M). The organic phase was dried and concentrated to dryness, leaving crude 2-(3,4,5-trimethoxyphenyl)-2-acetoxy-N-methyl-N-3,4-ethylenedioxybenzylacetamide (7.27 g).

後処理

  1. temperatureThe solution was refluxed for 30 minutes
  2. additionwas added
  3. washafter which it was washed with aqueous hydrochloric acid (20 ml, 1M)
  4. customThe organic phase was dried
  5. concentrationconcentrated to dryness

出典と根拠

ORDレコード
ord-04326d94108544258b1eec3c27956ad5
出典データセット
uspto-grants-2011_10
DOI
10.6084/m9.figshare.5104873.v1
特許番号
US08044067B2

反応ノート

読み込み中…

このページの内容参加物実験手順後処理出典と根拠反応ノート