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Trifluoroacetic acid → 4-(3-Benzyloxy-benzylidene)-piperidine trifluoroacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | 4-(3-Benzyloxy-benzylidene)-piperidine-1-carboxylic acid tert-butyl ester | HCID 66876001 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 4-(3-Benzyloxy-benzylidene)-piperidine trifluoroacetate | HCID 66876189 | — |
反応手順
4-(3-Benzyloxy-benzylidene)-piperidine-1-carboxylic acid tert-butyl ester (534 mg, 1.4 mmol) from Step 2 was dissolved in CH2Cl2 (5 mL) and treated with trifluoroacetic acid (1.05 mL, 14.1 mmol). After 2 hours, the solution was concentrated to provide the title compound which was used without further purification (550 mg).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08044052B2 |
| 出典データセット | uspto-grants-2011_10 |
| ORD ID | ord-4fc2c6e0d9814ed1af959ba0dce20d27 |
| 出典メモ | uspto-grants-2011_10 |