Trifluoroacetic acid → 2-(3-(Phenyl(piperidin-4-ylidene)methyl)phenoxy)-5-(trifluoromethyl)pyridine trifluoroacetate

HRID 1666482ノート

反応式

HRID 1666482 の反応式
[C:1]1([C:7]([C:21]2[CH:26]=[CH:25][CH:24]=[C:23]([O:27][C:28]3[CH:33]=[CH:32][C:31]([C:34]([F:37])([F:36])[F:35])=[CH:30][N:29]=3)[CH:22]=2)=[C:8]2[CH2:13][CH2:12][N:11](C(OC(C)(C)C)=O)[CH2:10][CH2:9]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41]>C(Cl)Cl>[F:38][C:39]([F:44])([F:43])[C:40]([OH:42])=[O:41].[C:1]1([C:7](=[C:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[C:21]2[CH:22]=[C:23]([CH:24]=[CH:25][CH:26]=2)[O:27][C:28]2[CH:33]=[CH:32][C:31]([C:34]([F:36])([F:37])[F:35])=[CH:30][N:29]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 67445311tert-Butyl 4-(phenyl(3-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)methylene)piperidine-1-carboxylate

生成物 1

HCID 866239142-(3-(Phenyl(piperidin-4-ylidene)methyl)phenoxy)-5-(trifluoromethyl)pyridine trifluoroacetate収率 70%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

To a solution of tert-butyl 4-(phenyl(3-(5-(trifluoromethyl)pyridin-2-yloxy)phenyl)methylene)piperidine-1-carboxylate in CH2Cl2 (3 mL) was added trifluoroacetic acid (0.5 mL). The reaction was stirred overnight. The reaction was concentrated, redissolved in CH2Cl2 and concentrated again to give the title compound as an oil (33.7 mg, 70% yield).

後処理

  1. concentrationThe reaction was concentrated
  2. dissolutionredissolved in CH2Cl2
  3. concentrationconcentrated again

出典と根拠

ORDレコード
ord-4885579f4db146f69950e549ddf599bd
出典データセット
uspto-grants-2011_10
特許番号
US08044052B2

反応ノート

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