Trifluoroacetic acid → HCID 66875752、化合物

HRID 1666514ノート

反応式

HRID 1666514 の反応式
C(OC([N:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:20]=[CH:19][CH:18]=[C:17]([O:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=3)[CH:16]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31]>ClCCl>[F:28][C:29]([F:34])([F:33])[C:30]([OH:32])=[O:31].[NH:8]1[CH2:13][CH2:12][C:11](=[CH:14][C:15]2[CH:16]=[C:17]([CH:18]=[CH:19][CH:20]=2)[O:21][C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][N:23]=2)[CH2:10][CH2:9]1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 66875697HCID 66875697、化合物

生成物 1

HCID 66875752HCID 66875752、化合物

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of tert-butyl-4-(3-(pyridin-2-yloxy)benzylidene)piperidine-1-carboxylate (0.483 g) in dichloromethane (2.5 mL, 0.53 M) was treated with trifluoroacetic acid (2.5 mL). The reaction was allowed to stir for 3 hours, then concentrated to give an oil. The oil was used without purification. 0.652 g, quantitative yield.

後処理

  1. concentrationconcentrated
  2. customto give an oil
  3. customThe oil was used without purification

出典と根拠

ORDレコード
ord-9815bf5f1fed45d387b46bfb3130815d
出典データセット
uspto-grants-2011_10
特許番号
US08044052B2

反応ノート

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