5-Methyl-2-((2-nitrophenyl)amino)-3-thiophenecarbonitrile → 2-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile

HRID 1666932ノート

反応式

HRID 1666932 の反応式
[N+:1]([C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[NH:6][C:7]1[S:8][C:9]([CH3:14])=[CH:10][C:11]=1[C:12]#[N:13])([O-])=O>C(OCC)(=O)C.[Pd]>[NH2:1][C:4]1[CH:18]=[CH:17][CH:16]=[CH:15][C:5]=1[NH:6][C:7]1[S:8][C:9]([CH3:14])=[CH:10][C:11]=1[C:12]#[N:13]

参加物

4

反応物 1

HCID 3954605-Methyl-2-((2-nitrophenyl)amino)-3-thiophenecarbonitrile

生成物 1

HCID 674452622-(2-Aminoanilino)-5-methylthiophene-3-carbonitrile

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

2-(2-Nitroanilino)-5-methylthiophene-3-carbonitrile (100 g) is taken in ethyl acetate (1000 ml). The reaction mixture is then hydrogenated by 5% Pd/C (15 g) at 50-55° C. at 10-12 Kg pressure. The reaction mixture is filtered, and ethyl acetate is distilled off to get the title compound.

後処理

  1. filtrationThe reaction mixture is filtered
  2. distillationethyl acetate is distilled off

出典と根拠

ORDレコード
ord-302a18ee9fe34f6aa6145ec243e4ccee
出典データセット
uspto-grants-2011_10
特許番号
US08044196B2

反応ノート

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