Trifluoroacetic acid → 3,3-Bis(4-fluorophenyl)-1-(2-(piperazin-1-yl)ethyl)pyrrolidin-2-one

HRID 1667131ノート

反応式

HRID 1667131 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([C:29]3[CH:34]=[CH:33][C:32]([F:35])=[CH:31][CH:30]=3)[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[C:9]2=[O:28])=[CH:4][CH:3]=1.FC(F)(F)C(O)=O.C(N(CC)CC)C>ClCCl>[F:35][C:32]1[CH:33]=[CH:34][C:29]([C:8]2([C:5]3[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=3)[CH2:12][CH2:11][N:10]([CH2:13][CH2:14][N:15]3[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]3)[C:9]2=[O:28])=[CH:30][CH:31]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 8471TriethylamineHCID 67359885Tert-butyl 4-(2-(3,3-bis(4-fluorophenyl)-2-oxopyrrolidin-1-yl)ethyl)piperazine-1-carboxylate

生成物 1

HCID 674430113,3-Bis(4-fluorophenyl)-1-(2-(piperazin-1-yl)ethyl)pyrrolidin-2-one

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

The product from Example 63B (2.00 g, 4.12 mmol) was dissolved in dichloromethane (40 mL) and treated with trifluoroacetic acid (7.40 g, 64.9 mmol) at 0° C. The reaction was allowed to come to room temperature and stirred for 1 hour. The reaction was neutralized with triethylamine and concentrated. The residue was taken into ethyl acetate, and then it was washed with water and brine, dried with MgSO4, filtered and concentrated to give the title compound. MS (DCI) m/z 386.2 (M+H)+.

後処理

  1. customto come to room temperature
  2. concentrationconcentrated
  3. washit was washed with water and brine
  4. dry with materialdried with MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-008ab5481fc1483db7a204bdbd047ecb
出典データセット
uspto-grants-2011_10
特許番号
US08044069B2

反応ノート

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