Potassium thiocyanate → 2-Oxo-2-[3-(trifluoromethyl)phenyl]ethyl thiocyanate
反応式
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4].[S-:15][C:16]#[N:17].[K+]>C(O)C>[S:15]([CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([C:11]([F:14])([F:13])[F:12])[CH:6]=1)=[O:4])[C:16]#[N:17]参加物
4
実験手順
A mixture of 10.17 g (36.83 mmole) of 2-bromo-1-(3-trifluoromethyl-phenyl)-ethanone, 4.07 g (41.98 mmole) of potassium thiocyanate and ethanol was heated at reflux for 2 hours. The cooled mixture was concentrated under reduced pressure. The residue was taken up in 225 mL of ethyl acetate, washed three times with 50 mL of water, then 50 mL of brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure to give 8.85 g of 2-thiocyanato-1-(3-trifluoromethyl-phenyl)-ethanone.
後処理
- temperaturewas heated
- temperatureat reflux for 2 hours
- concentrationThe cooled mixture was concentrated under reduced pressure
- washwashed three times with 50 mL of water
- dry with material50 mL of brine, dried over anhydrous sodium sulfate
- filtrationfiltered
- concentrationconcentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-466333d98a5a42f2bc4e140cf90f86fd
- 出典データセット
- uspto-grants-2011_10
- 特許番号
- US08044213B2
反応ノート
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