7-Hydroxy-8-nitro-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester → 1,1-Dimethylethyl 7-amino-8-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

HRID 1668561ノート

反応式

HRID 1668561 の反応式
[OH:1][C:2]1[C:19]([N+:20]([O-])=O)=[CH:18][C:5]2[CH2:6][CH2:7][N:8]([C:11]([O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[O:12])[CH2:9][CH2:10][C:4]=2[CH:3]=1>CCO.[Pd]>[NH2:20][C:19]1[C:2]([OH:1])=[CH:3][C:4]2[CH2:10][CH2:9][N:8]([C:11]([O:13][C:14]([CH3:16])([CH3:17])[CH3:15])=[O:12])[CH2:7][CH2:6][C:5]=2[CH:18]=1

参加物

4

反応物 1

HCID 589728117-Hydroxy-8-nitro-1,2,4,5-tetrahydro-benzo[d]azepine-3-carboxylic acid tert-butyl ester

生成物 1

HCID 591504721,1-Dimethylethyl 7-amino-8-hydroxy-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

1,1-Dimethylethyl 7-hydroxy-8-nitro-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate (8.2 g) was hydrogenated for 4 h under atmospheric pressure and 25° C. in the presence of 10% Pd/C (1.4 g) in EtOH (200 ml). The catalyst was removed by filtration and volatiles evaporated to provide the title compound as a grey solid (7.4 g).

後処理

  1. customThe catalyst was removed by filtration and volatiles
  2. customevaporated

出典と根拠

ORDレコード
ord-8a02e9e50c264216918e111120e3c193
出典データセット
uspto-grants-2011_08
特許番号
US07989444B2

反応ノート

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