HCID 11558165、化合物 → 2-Propanone, 1-(1-piperazinyl)-
反応式
[C:1]([CH2:4][N:5]1[CH2:10][CH2:9][N:8](C(OCC2C=CC=CC=2)=O)[CH2:7][CH2:6]1)(=[O:3])[CH3:2]>[Pd].C(O)C>[C:1]([CH2:4][N:5]1[CH2:10][CH2:9][NH:8][CH2:7][CH2:6]1)(=[O:3])[CH3:2]参加物
4
実験手順
10% Palladium-on-charcoal catalyst (0.3 g) was added to a solution of benzyl 4-(acetylmethyl)-1-piperazinecarboxylate (3.7 g) in ethanol (45 ml). The reaction mixture was stirred under hydrogen at 3 atmospheres pressure for 1.5 hours. The catalyst was removed by filtration and the solvent removed from the filtrate by evaporation. The residue was purified by flash chromatography using dichloromethane/methanol saturated with ammonia (3.5 M) (97/3). Evaporation of the solvent gave 1-(acetylmethyl)piperazine (1.5 g, 80%) as a yellow oil.
後処理
- customThe catalyst was removed by filtration
- customthe solvent removed from the filtrate by evaporation
- customThe residue was purified by flash chromatography
- customEvaporation of the solvent
出典と根拠
- ORDレコード
- ord-dd8cb76623bf4354b6418556ada73599
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989460B2
反応ノート
読み込み中…