Aminoacetaldehyde dimethyl acetal → HCID 178495904、化合物
反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=O)[S:5][C:6]=1[CH3:7].[CH3:10][O:11][CH:12]([O:15][CH3:16])[CH2:13][NH2:14]>O>[Br:1][C:2]1[CH:3]=[C:4](/[CH:8]=[N:14]/[CH2:13][CH:12]([O:15][CH3:16])[O:11][CH3:10])[S:5][C:6]=1[CH3:7]参加物
4
反応条件
- 温度
- 120 °C
実験手順
4-bromo-5-methylthiophene-2-carbaldehyde (11.00 g, 53.6 mmol) was treated with 2,2-dimethoxyethanamine (17.5 ml, 161 mmol) and the mixture stirred at 120° C. for 12 hours. The reaction was poured into water (50 ml) and stirred for 1 hour and extracted with ethyl acetate. The organic layer was washed (2×) with an aqueous saturated solution of sodium bicarbonate, then with water and then brine. The organic layer was then dried with sodium sulfate, concentrated under reduced pressure and placed under a vacuum line to give (E)-N-((4-bromo-5-methylthiophen-2-yl)methylene)-2,2-dimethoxyethanamine.