Sodium borohydride → 1-(4'-Trifluoromethyl-biphenyl-4-yl)-butan-2-ol

HRID 1669289ノート

反応式

HRID 1669289 の反応式
[F:1][C:2]([F:21])([F:20])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][C:16](=[O:19])[CH2:17][CH3:18])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[BH4-].[Na+]>C(O)C>[F:1][C:2]([F:20])([F:21])[C:3]1[CH:4]=[CH:5][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH2:15][CH:16]([OH:19])[CH2:17][CH3:18])=[CH:11][CH:10]=2)=[CH:7][CH:8]=1

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 673416551-(4'-Trifluoromethyl-biphenyl-4-yl)-butan-2-one

生成物 1

HCID 673421621-(4'-Trifluoromethyl-biphenyl-4-yl)-butan-2-ol収率 94%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

反応条件

温度
0 °C

実験手順

To an ethanol (2 mL) solution of 1-(4′-trifluoromethyl-biphenyl-4-yl)-butan-2-one (0.093 g, 0.32 mmol) is added sodium borohydride (0.048 g, 1.27 mmol) at 0° C. The reaction mixture is stirred one hour at 0° C., quenched by saturated sodium bicarbonate solution (1 mL) and stirred for five minutes, extracted with ethyl acetate. Organic phase is washed with saturated sodium bicarbonate and brine dried over sodium sulfate, filtered and concentrated to give 0.088 g (0.30 mmol, 94%) of title compound.

後処理

  1. customquenched by saturated sodium bicarbonate solution (1 mL)
  2. stirringstirred for five minutes
  3. extractionextracted with ethyl acetate
  4. washOrganic phase is washed with saturated sodium bicarbonate and brine
  5. dry with materialdried over sodium sulfate
  6. filtrationfiltered
  7. concentrationconcentrated

出典と根拠

ORDレコード
ord-ba3e0d99e1374258a89fd36e1f9329ea
出典データセット
uspto-grants-2011_08
特許番号
US07989457B2

反応ノート

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