Hydrochloric Acid → 3-(2-Cyanoethyl)benzaldehyde

HRID 1669355ノート

反応式

HRID 1669355 の反応式
[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:11]2OCC[O:12]2)[CH:8]=[CH:9][CH:10]=1)#[N:2].Cl>O1CCCC1>[C:1]([CH2:3][CH2:4][C:5]1[CH:6]=[C:7]([CH:8]=[CH:9][CH:10]=1)[CH:11]=[O:12])#[N:2]

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 231317192-[3-(2-Cyanoethyl)phenyl]-[1,3]dioxolane

生成物 1

HCID 114992593-(2-Cyanoethyl)benzaldehyde収率 97.2%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To 3.52 g of 2-[3-(2-cyanoethyl)phenyl]-[1,3]dioxolane was added 60 ml of tetrahydrofuran to dissolve this, and 20 ml of 6 N hydrochloric acid was added. After stirred at room temperature overnight and then concentrated under reduced pressure, ethyl acetate was added, and this was washed successively with an aqueous potassium carbonate solution and an aqueous saturated sodium chloride solution. After dried over anhydrous magnesium sulfate, concentration under reduced pressure afforded 2.68 g of 3-(2-cyanoethyl)benzaldehyde [Compound No. (m)].

後処理

  1. additionwas added
  2. concentrationconcentrated under reduced pressure, ethyl acetate
  3. additionwas added
  4. washthis was washed successively with an aqueous potassium carbonate solution
  5. dry with materialAfter dried over anhydrous magnesium sulfate, concentration under reduced pressure

出典と根拠

ORDレコード
ord-90734633cab14b5097d58ef503e44dba
出典データセット
uspto-grants-2011_08
特許番号
US07989478B2

反応ノート

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