Tetrabutylammonium Fluoride → methyl 1-allyl-3-cyclohexyl-2-[2-(hydroxymethyl)-4-methoxyphenyl]-1H-indole-6-carboxylate

HRID 1669432ノート

反応式

HRID 1669432 の反応式
[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=2)[C:6]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[C:5]1[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[CH2:31][O:32][Si](C(C)C)(C(C)C)C(C)C)[CH:2]=[CH2:3].[F-].C([N+](CCCC)(CCCC)CCCC)CCC>C1COCC1>[CH2:1]([N:4]1[C:12]2[C:7](=[CH:8][CH:9]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:11]=2)[C:6]([CH:17]2[CH2:22][CH2:21][CH2:20][CH2:19][CH2:18]2)=[C:5]1[C:23]1[CH:28]=[CH:27][C:26]([O:29][CH3:30])=[CH:25][C:24]=1[CH2:31][OH:32])[CH:2]=[CH2:3]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 67344093HCID 67344093、化合物

生成物 1

HCID 67345867methyl 1-allyl-3-cyclohexyl-2-[2-(hydroxymethyl)-4-methoxyphenyl]-1H-indole-6-carboxylate収率 88%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒2 回

実験手順

Methyl 1-allyl-3-cyclohexyl-2-(4-methoxy-2-{[(triisopropylsilyl)oxy]methyl}phenyl)-1H-indole-6-carboxylate (1 eq) was dissolved in THF (0.28M solution) and a 1M solution of tetrabutylammonium fluoride in THF (1 eq) was added. The mixture was stirred at RT for 2 h, then all volatiles were evaporated in vacuo and the residual material was dissolved in Et2O. The solution was washed with 1N HCl, saturated aq. NaHCO3 solution and with brine. The organic phase was dried over Na2SO4 and evaporated in vacuo. The residual material was purified by FC (PE:EtOAc, 8:2). After evaporation of the solvents the product was obtained as colourless foam (88%). (ES+): m/z 434.2 (M+H)+.

後処理

  1. customall volatiles were evaporated in vacuo
  2. dissolutionthe residual material was dissolved in Et2O
  3. washThe solution was washed with 1N HCl, saturated aq. NaHCO3 solution and with brine
  4. dry with materialThe organic phase was dried over Na2SO4
  5. customevaporated in vacuo
  6. customThe residual material was purified by FC (PE:EtOAc, 8:2)
  7. customAfter evaporation of the solvents the product

出典と根拠

ORDレコード
ord-32d345ae3910424da8d23045ad11626e
出典データセット
uspto-grants-2011_08
特許番号
US07989438B2

反応ノート

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