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O-Cresol → 1-(Methoxymethoxy)-2-methylbenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | O-Cresol | HCID 335 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Chloromethyl Methyl Ether | HCID 7864 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Water | HCID 962 | — |
| 溶媒 | DMF ether | HCID 19966313 | — |
| 生成物 | 1-(Methoxymethoxy)-2-methylbenzene | HCID 3839351 | — |
反応手順
To a suspension of NaH (60% dispersion in mineral oil; 1.2 eq) in Et2O/DMF (5:1, 0.2M) a solution of o-cresol in Et2O (1 eq, 2M) was added dropwise over 15 min. A solution of MOMCl in Et2O (1.1 eq, 2M) was added and the mixture was stirred for 30 min then poured into H2O and extracted with Et2O. The combined organic extracts were washed with 1N NaOH, H2O and brine, dried over Na2SO4, filtered and evaporated in vacuo to give the title compound. The product was used in the next step without further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07989438B2 |
| 出典データセット | uspto-grants-2011_08 |
| ORD ID | ord-20b43335f7ed4d1abe3450533abe617c |
| 出典メモ | uspto-grants-2011_08 |