反应详情

To a suspension of NaH (60% dispersion in mineral oil; 1.2 eq) in Et2O/DMF (5:1, 0.2M) a solution of o-cresol in Et2O (1 eq, 2M) was added dropwise over 15 min. A solution of MOMCl in Et2O (1.1 eq, 2M) was added and the mixture was stirred for 30 min then poured into H2O and extracted with Et2O. The combined organic extracts were washed with 1N NaOH, H2O and brine, dried over Na2SO4, filtered and evaporated in vacuo to give the title compound. The product was used in the next step without further purification.

1. additionwas added dropwise over 15 min
2. extractionextracted with Et2O
3. washThe combined organic extracts were washed with 1N NaOH, H2O and brine
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. customevaporated in vacuo