Water → Methyl 4-azidobutanoate
反応式
[CH3:1][O:2][C:3](=[O:8])[CH2:4][CH2:5][CH2:6]Br.[N-:9]=[N+:10]=[N-:11].[Na+].O>CS(C)=O>[N:9]([CH2:6][CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:8])=[N+:10]=[N-:11]参加物
5
反応条件
- 温度
- 47.5 °C
実験手順
To a solution of methyl-4-bromobutyrate in DMSO (0.6 M) was added with stirring NaN3 (1.5 eq). The suspension was heated (45-50° C., oil bath) with stirring for 5 h. After cooling, H2O was added and the mixture extracted with Et2O. The organic extracts were washed with brine and dried over Na2SO4. The solvent was removed in vacuo and the crude oil used without further purification (99%).
後処理
- temperatureAfter cooling
- extractionthe mixture extracted with Et2O
- washThe organic extracts were washed with brine
- dry with materialdried over Na2SO4
- customThe solvent was removed in vacuo
- customthe crude oil used without further purification (99%)
出典と根拠
- ORDレコード
- ord-922c7435902b486d99f0d73efd64851c
- 出典データセット
- uspto-grants-2011_08
- 特許番号
- US07989438B2
反応ノート
読み込み中…