1-Benzyl-4-iodobenzene → (R)-[4-(4-Benzyl-phenoxy)-phenyl]-tert-butoxycarbonylamino acetic acid methyl ester

HRID 1669513

反応式

HRID 1669513 の反応式
[CH3:1][O:2][C:3](=[O:20])[C@H:4]([NH:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[CH:7][CH:6]=1.[CH:21]1[CH:26]=[CH:25][C:24]([CH2:27][C:28]2[CH:33]=[CH:32][C:31](I)=[CH:30][CH:29]=2)=[CH:23][CH:22]=1>>[CH3:1][O:2][C:3](=[O:20])[C@@H:4]([C:5]1[CH:6]=[CH:7][C:8]([O:11][C:31]2[CH:32]=[CH:33][C:28]([CH2:27][C:24]3[CH:25]=[CH:26][CH:21]=[CH:22][CH:23]=3)=[CH:29][CH:30]=2)=[CH:9][CH:10]=1)[NH:12][C:13]([O:15][C:16]([CH3:17])([CH3:19])[CH3:18])=[O:14]

参加物

3

反応物 2

HCID 27593641-Benzyl-4-iodobenzeneHCID 10934864Methyl (2R)-2-{[(tert-butoxy)carbonyl]amino}-2-(4-hydroxyphenyl)acetate

生成物 1

HCID 67352764(R)-[4-(4-Benzyl-phenoxy)-phenyl]-tert-butoxycarbonylamino acetic acid methyl ester収率 50%

実験手順

The title compound was prepared from the product from step 1 (1.3 g, 4.6 mmol) and 4-iododiphenylmethane (2.0 g, 6.9 mmol) using the Step 4 procedure of example 1 with 50% yield (1.1 g). 1HNMR (CDCl3) 1.43 (s, 9H), 3.73 (s, 3H), 3.97 (s, 2H), 5.29 (m, 1H), 5.50 (m, 1H), 6.94 (m, 4H), 7.15 (d, J=6.8 Hz, 2H), 7.20 (m, 3H), 7.30 (m, 4H), MS m/z 448 (M+1).

出典と根拠

ORDレコード
ord-1bff4306ab284ae98951411437d82cc4
出典データセット
uspto-grants-2011_08
特許番号
US07989480B2

関連ノート

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