Benzamide → 2-(3-fluorophenyl)-7-methoxy-8-methyl-1H-quinazolin-4-one

反応式

[NH2:1][C:2]1[C:10]([CH3:11])=[C:9]([O:12][CH3:13])[CH:8]=[CH:7][C:3]=1[C:4]([NH2:6])=[O:5].C(N)(=O)C1C=CC=CC=1.[F:23][C:24]1[CH:25]=[C:26]([CH:30]=[CH:31][CH:32]=1)[C:27](Cl)=O>>[F:23][C:24]1[CH:25]=[C:26]([C:27]2[N:6]=[C:4]([OH:5])[C:3]3[C:2](=[C:10]([CH3:11])[C:9]([O:12][CH3:13])=[CH:8][CH:7]=3)[N:1]=2)[CH:30]=[CH:31][CH:32]=1

参加物

反応物 3

HCID 2331Benzamide

HCID 743763-Fluorobenzoyl chloride

HCID 591654352-Amino-4-methoxy-3-methylbenzamide

生成物 1

HCID 1784877302-(3-fluorophenyl)-7-methoxy-8-methyl-1H-quinazolin-4-one収率 73%

実験手順

The general procedure described in Example 31 was followed using 2-amino-4-methoxy-3-methyl benzamide as benzamide derivative [A] and 3-fluoro-benzoyl chloride as acid chloride [B], which gave the title compound (2.1 g, 73%), [M+H]=271.

出典と根拠

ORDレコード: ord-fbe839a16e294ea290a8a79f062aea4c
出典データセット: uspto-grants-2011_08
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07989471B2

反応ノート

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